They did know each other. On the 2Pac 4 Ever DVD, there is an interview with Bizzy Bone, and he said that they first met Pac after some awards (during Pac's Death Row days), and Pac greeted them and took a picture. (A different interview with Krayzie Bone tells a similar story, saying that their crews ran into each other at a hotel, probably staying there for the awards, and that Pac said he was a fan and listened to their music when he was locked up.) In an older issue of the Source (right before The Art of War was released), Layzie Bone said that Pac was a "cool ass nigga" and brought a bunch of weed for all of them to smoke.